Organized by

Under the patronage
of the French Minister of Health

Under the auspices of

National Federation of Comprehensive Cancer Centers

SYMPOSIA

SY01 THYROID IN THE FACE OF CHANGING IODINE INTAKE - Sunday 12 Sept. 11:30 am - 01:00 pm

The changing epidemiology of iodine deficiency
Mu Li (Australia)
Worldwide changes in iodine intake
Eduardo Pretell (Peru)
Novel strategies for control of iodine deficiency
Michael Zimmermann (Switzerland)
Consequences of changes in iodine intake for the occurrence of thyroid disorders
Peter Laurberg (Denmark)

SY02 THE TSH RECEPTOR AND AUTO-IMMUNE THYROID DISEASE - Sunday 12 Sept. 11:30 am - 01:00 pm

Polymorphisms in the TSH receptor
Stephen C.L. Gough (UK)
Model of TSH receptor activation by ligands and autoantibodies
Gilbert Vassart (Belgium)
The ectodomain is a key-determinant of tsh receptor signalling mechanism
Gunnar Kleinau (Germany)
Animal models of Graves’ disease
Yuji Nagayama (Japan)

SY03 NEW INSIGHTS INTO THE CONTROL OF THYROID HORMONE ACTION - Sunday 12 Sept. 11:30 am - 01:00 pm

Entry & exit of thyroid hormone into/from tissues
Theo Visser (The Netherlands)
Intracellular thyroid hormone activation and inactivation by deiodinases
Domenico Salvatore (Italy)
Molecular models of ligand-TR interactions
Paul Webb (USA)
Co-activators and co-repressors for regulating thyroid hormone receptors
Fred Wondisford (USA)

SY04 THYROID NODULES - Sunday 12 Sept. 4:45 pm - 6:15 pm

Elastography in the diagnosis of thyroid nodules
Paolo Vitti (Italy)
Molecular diagnosis of thyroid nodules
Yuri Nikiforov (USA)
Can drugs shrink thyroid nodules?
Martin Grussendorf (Germany)
Treatment of Multinodular goiter by rhTSH-stimulated 131I ablation
Hans Graf (Brazil)

SY05 NUCLEAR ACCIDENTS AND THYROID BLOCKADE: ARE WE READY? (Sponsored by Electricité de France)
Sunday 12 Sept. 4:45 pm - 6:15 pm

Chernobyl consequences: Thyroid dysfunction and cancer
Michael Tuttle (USA)
Are there health consequences in the vicinity of nuclear power plants in normal functioning conditions ?
Jacques Esteve (France)
Iodine thyroid blocking in nuclear and radiological emergencies
Shunichi Yamashita (Japan)
The predistribution of potassium iodine tablets : the French experience
Yves Garcier (France)

SY06 ALLAN-HERNDON-DUDLEY SYNDROME AND THYROID HORMONE TRANSPORTERS - Sunday 12 Sept. 4:45 pm - 6:15 pm

Genetics of plasma membrane transporters.
Edith Friesema (The Netherlands)
Early attempts in the treatment of MCT8 gene defects
Samuel Refetoff (USA)
Molecular basis for differences in human and mouse brain phenotypes
Ulrich Schweizer (Germany)
Thyroid hormone transporters in the brain
Grant Anderson (USA)

SY07 NON-MAMMALIAN MODELS IN THYROID RESEARCH - Sunday 12 Sept. 4:45 pm - 6:15 pm

The Zebrafish
Robert Opitz (Belgium)
Birds (Quail)
Takashi Yoshimura (Japan)
Chicken
Veerle Darras (Belgium)
Amphibia
Yun-Bo Shi (USA)

SY08 SELENIUM AND THE THYROID - Monday 13 Sept. 11:30 am - 01:00 pm

Selenium intake and thyroid hormone physiology
Lutz Schomburg (Germany)
Selenium and thyroid autoantibodies
Silvia Eskes (The Netherlands)
Selenium in mild Graves’ Orbitopathy
Claudio Marcocci (Italy)
Maternal selenium status, thyroid function, and pregnancy outcome
Victor Pop (The Netherlands)

SY09 MOLECULAR MECHANISMS OF THYROID CANCER – BASIC - Monday 13 Sept. 11:30 am - 01:00 pm

Micro-RNA
Edna Teruko Kimura (Brazil)
Tumor immunology and associated macrophages
James Fagin (USA)
Thyroid cancer stem cells
Norisato Mitsutake (Japan)

SY10 HYPOTHALAMIC CONTROL OF ENERGY HOMEOSTASIS - Monday 13 Sept. 11:30 am - 01:00 pm

Thyroid hormone signalling and metabolic control
Anthony Hollenberg (USA)
Modulation of hepatic glucose production by central thyroid hormone action
Lars Klieverik (The Netherlands)
The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor in health and disease
Csaba Fekete (Hungary)
Leptin signalling in the hypothalamo-pituitary-thyroid axis
Egberto G Moura (Brazil)

SY11 MECHANISM-BASED THERAPEUTICS FOR ADVANCED THYROID CANCERS - Monday 13 Sept. 4:45 pm - 6:15 pm

Overview of therapeutic targets
Massimo Santoro (Italy)
Selection of patients for targeted therapies
Lars Bastholt (Denmark)
Results of clinical trials of targeted therapies
Dave Pfister (USA)
Management of off-target toxicity
Manisha Shah (USA)

SY12 MANAGEMENT OF GRAVES’ OPHTHALMOPATHY (GO) - Monday 13 Sept. 4:45 pm - 6:15 pm

Immunopathogenesis of GO: Where do we stand?
Rebecca Bahn (USA)
Ethnic differences in the clinical presentation of GO
Daphne Khoo (Singapore)
Optimal use of steroids in GO and the role of high dose IV methyl-prednisolone
Luigi Bartalena (Italy)
Novel treatments of GO
Mario Salvi (Italy)

SY13 TRANSPORTERS IN THYROID CELL BIOLOGY - Monday 13 Sept. 4:45 pm - 6:15 pm

Structure-function relationship of the sodium/iodide symporter (NIS)
Nancy Carrasco (USA)
MCT8 as thyroid hormone exporter in thyroid cells
Caterina Di Cosmo (USA)
Pendrin and apical iodide transport
Peter Kopp (USA)
Role of ClC5 in the thyroid
Marie-France van den Hove (Belgium)

SY14 DEVELOPMENT AND APPLICATIONS OF NOVEL THYROID HORMONE ANALOGUES - Monday 13 Sept.4:45 pm - 6:15 pm

Physiological and pharmacological actions of thyroid hormone analogues
Thomas Scanlan (USA)
Cardiac effects of thyronamines
Ricardo Zucchi (Italy)
Use of TR-beta selective agonists in metabolic syndrome
Miriam O. Ribeiro (Brazil)
Non-genomic action of thyroid hormone analogues
Paul Davis (USA)

SY15 ADVANCES IN SURGICAL THERAPY OF THYROIDCANCER - Tuesday 14 Sept. 11:30 am - 01:00 pm

Minimizing surgical risks (nerve monitoring, calcium management)
Paolo Miccoli (Italy)
New methods (robotics, minimally invasive surgery)
Woong Youn Chung (Korea)
Controversy on central neck dissection
Gerard Doherty (USA)
Re-operation – when and how ?
David Steward (USA)

SY16 IMMUNO MECHANISMS IN AUTOIMMUNE THYROID DISEASES (AITD): NEW DEVELOPMENTS AND FUTURE DIRECTIONS - Tuesday 14 Sept.11:30 am - 01:00 pm

Immunoregulation in a mouse model of Graves' disease
Basil Rapoport (USA)
Chemokines and thyroid autoimmunity
Sergio Lira (USA)
The role of dendritic cells in AITD
Claudia Pellizas (Argentina)
Vitamin D and AITD
Klaus Badenhoop (Germany)

SY17 MOLECULAR MECHANISMS OF THYROID CANCER – TRANSLATIONAL - Tuesday 14 Sept. 11:30 am - 01:00 pm

Defining poorly differentiated thyroid cancer
Fulvio Basolo (Italy)
PI3K pathway in cancer progression
Matthew Ringel (USA)
Sodium/Iodide transporter (NIS) dysregulation
Christine Spitzweg (Germany)
BRAF mutation
Janete Cerutti (Brazil)

SY18 PREGNANCY AND THYROID DISEASES - Wednesday 15 Sept. 11:30 am - 01:00 pm

T4 transport across the placenta
Shiao Chan (UK)
Treatment of hypothyroidism in pregnancy
Greg Brent (USA)
Treatment of hyperthyroidism in pregnancy
Graciela Alcaraz (Argentina)
Outcome of the CATS study in pregnant women
John Lazarus (UK)

SY19 MOLECULAR EPIDEMIOLOGY OF THYROID CANCER - Wednesday 15 Sept. 11:30 am - 01:00 pm

Population studies of genetic risk for thyroid cancer
Krystian Jazdzweski (USA)
Susceptibility to differentiated thyroid cancer
Erich Sturgis (USA)
Molecular signature of radiation induced thyroid tumors
Vladimir Saenko (Japan)
Molecular signature of spontaneous thyroid tumors
Adel El-Naggar (USA)

SY20 DEVELOPMENTAL ROLE OF DEIODINASES - Wednesday 15 Sept. 11:30 am - 01:00 pm

Role of deiodinases in adipogenesis
Jessica Hall (USA)
Deiodinases & senses (vision & hearing)
Douglas Forrest (USA)
Thyroid hormone action in bone
Cecilia Gouveia (Brazil)
Deiodinases & bone development
Graham Williams (UK)

SY21 ISSUES IN THE MANAGEMENT OF LOW-RISK THYROID CANCER - Wednesday 15 Sept. 4:45 pm - 6:15 pm

How to define low-risk patients for initial and long-term management ?
Ian Hay (USA)
Roles of surgery and RAI (emphasis on micro or minimally invasive FTC)
Paul Ladenson (USA)
Follow-up of the patients “less than total thyroidectomy-no radioactive iodine”
Koichi Ito (Japan)

SY22 GENETICS OF AUTOIMMUNE THYROID DISEASES (AITD) - Wednesday 15 Sept. 4:45 pm - 6:15 pm

Approaches to identifying AITD susceptibility genes
Simon Pearce (UK)
Ethnic differences in the genetics of AITD
Takashi Akamizu (Japan)
The role of detoxifying genes in AITD
Joao Romaldini (Brazil)
Polyglandular syndromes and AITD: Immunogenetic mechanisms
George Kahaly (Germany)

SY23 ROLE OF REACTIVE OXYGEN SPECIES IN THYROID CELL BIOLOGY - Wednesday 15 Sept. 4:45 pm - 6:15 pm

DUOX and its maturation factor
Helmut Grasberger (USA)
DUOX 1 and thyroid H2O2 generation
Xavier De Deken (Belgium)
Role of DUOX 2 and other NOX expression in the thyroid
Corinne Dupuy (France)
Hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors
Knut Krohn (Germany)

SY24 THYROID HORMONE ACTION AND LIPID/ENERGY METABOLISM - Wednesday 15 Sept. 4:45 pm - 6:15 pm

The role of TR-alpha in the regulation of energy metabolism
Jens Mittag (Sweden)
Bile acids and thyroid hormone activation
Georg Brabant (UK)
Cellular aspects of thyroid hormone effects on energy expenditure
Brian Kim (USA)
Thyroid hormone action in states of insulin-resistance and steatosis
Mary Elizabeth Patti (USA)

SY25 METASTATIC AND RECURRENT THYROID CANCER MANAGEMENT - Thursday 16 Sept. 09:30 am - 11:00 am

Radioiodine therapy and dosimetry
Markus Luster (Germany)
New imaging methods
Sophie Leboulleux (France)
Palliative therapies
Johannes Smit (The Netherlands)
Targeting the TSH receptor
Marvin Gershengorn (USA)

SY26 THYROID DISEASES AND THE METABOLIC SYNDROME - Thursday 16 Sept. 09:30 am - 11:00 am

Thyroid function and body weight
Elizabeth Pearce (USA)
Insulin resistance and the thyroid
Hugo Niepomniszcze (Argentina)
Thyroid function and blood pressure
Bjorn O. Asvold (Norway)
Thyroid function and lipid profile
Gabriella Brenta (Argentina)

SY27 CLINICALLY RELEVANT ALTERATIONS IN NON-THYROIDAL DISEASES ? Thursday 16 Sept. 09:30 am - 11:00 am

Consumptive hypothyroidism
Stephen Huang (USA)
Regulation of Deiodinase 3 expression in the stressed heart
Werner Simonides (The Netherlands)
The low T3 syndrome in cardiac patients and its treatment with T3
Giorgio Iervasi (Italy)
Nonthyroidal illness: adaptation or maladaptation, and what to do about it?
Greet van Den Berghe (Belgium)

SY28 THYROID DEVELOPMENT - Thursday 16 Sept. 09:30 am - 11:00 am

Using mice model of thyroid follicular cell development
Roberto di Lauro (Italy)
Thyroid gene expression during human fetal development
Michel Polak (France)
C cell development
Mikael Nilsson (Sweden)
Mendelian and non-Mendelian mechanisms of thyroid dysgenesis
Guy Van Vliet (Canada)